Marion Jost1*, Katharina Drerup1
1Department of Dermatology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
*Correspondence author: Marion Jost, MD, Department of Dermatology, UKSH Campus Kiel Arnold-Heller-Str. 3, 24105 Kiel, Germany; Email: [email protected]
Published Date: 03-02-2023
Copyright© 2023 by Jost M, et al. All rights reserved. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Clinical Image
A 46-year-old male patient came to our outpatient clinic in 2019 with nodules on the whole body, which first developed three years ago. He complained about severe pruritus (Fig. 1).
His medical history included Parkinson’s disease and schizophrenia. The only systemic medication he took was Trihexyphenidyl, an anticholinergic drug.
For topical treatment, he used different ointments with glucocorticosteroids. Skin examination revealed erythematous, hyperkeratotic plaques and nodules on the whole body with accentuation on the limbs. Genitals and mucous membranes were free.
Histopathology proved the diagnosis of nodular prurigo. Differential diagnoses included lichen planus verrucosus and multiple eruptive keratoacanthomas.
The patient received intravenous Naloxone twice for two to three days. Psychiatric therapy was recommended. Unfortunately, the patient didn’t present himself to our clinic again. Other therapy options are intraleasional triamcinolone, PUVA, ciclosporin, thalidomide, pregabalin or dupilumab.
Promising can be the interleukin-31 receptor antibody nemolizumab; it showed a more significant reduction in pruritus than a placebo in a recent trial.
Figure 1: Male patient with nodules on the whole body.
Funding
Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – 413490537.
Conflict of Interest
The authors have no conflict of interest to declare.
Clinical Image
Received Date: 11-01-2023
Accepted Date: 26-01-2023
Published Date: 03-02-2023
Copyright© 2023 by Jost M, et al. All rights reserved. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Citation: Jost M, et al. Just an Itch? J Dermatol Res. 2023;4(1):1-2.
Figure 1: Male patient with nodules on the whole body.
