A Natural Approach to Managing Tooth Hypersensitivity: A Randomized Clinical Trial

Jyoti Singh^1*, Mahesh Katariya¹, Prasun Bandyopadhyay¹, SG Vyas¹

¹Dabur Research and Development Centre, Ghaziabad, Uttar Pradesh, India

*Correspondence author: Jyoti Singh, Dabur Research and Development Centre, Ghaziabad, Uttar Pradesh, India;
E-mail: [email protected]

Citation: Singh J, et al. A Natural Approach to Managing Tooth Hypersensitivity: A Randomized Clinical Trial. J Dental Health Oral Res. 2025;6(2):1-7.

Copyright^© 2025 by Singh J, et al. All rights reserved. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Table 1: Test product details.

Results and Discussion

Plaque Index

Compared to the baseline, a 38.04% reduction in plaque was observed at 1 minute and 30 minutes after brushing on Day 1. After 30 days of continuous use of Dabur Red Paste , a statistically significant 59.88% reduction in plaque was recorded at both time points. By Day 60, the reduction was 71.00% at 1 minute and 30 minutes post-brushing. On Day 61, prior to using the test product, a 53.84% reduction in plaque was observed compared to the baseline on Day 1. The results demonstrated consistent and statistically significant plaque reduction across all time points (p-value < 0.0001).

Gingivitis Index

Compared to the baseline, no change in gingivitis was observed on Day 1 at 1 minute and 30 minutes after brushing. By Day 30, a 28.34% reduction in gingivitis was recorded at the same time points (p-value < 0.0001). After 60 days of continuous use of Dabur Red Paste, a 52.51% reduction in gingivitis was observed at 1 minute and 30 minutes post-brushing (p-value<0.0001). On Day 61, prior to brushing, a statistically significant 52.51% reduction in gingivitis was noted compared to the baseline on Day 1 (p-value < 0.0001). These findings indicate that the test product effectively reduces gingivitis with consistent use over time.

Root Caries

On Day 01, 19 subjects (65.52%) scored as Code 1, indicating a demarcated area on the root surface or at the cementoenamel junction that was discolored but without cavitation (loss of anatomical contour <0.5 mm). Additionally, 10 subjects (34.48%) scored as Code 2, indicating discoloration accompanied by cavitation (loss of anatomical contour ≥0.5 mm). With the usage of the test product there was no any change observed in the root caries throughout the study period.

Teeth Sensitivity- Tactile Method

After using Dabur Red Paste, a 16% (1.19X) reduction in tooth sensitivity was observed on Day 1 at 1 minute and 30 minutes post-brushing. By Day 30, the reduction was 36.50% (1.57X) at the same time points. Following 60 days of continuous use, the reduction reached 57.50% (2.35X) at 1 minute and 30 minutes post-brushing. The results were statistically significant across all time points (p-value < 0.001). These findings highlight the test product efficacy in significantly reducing tooth sensitivity with consistent use over time) (Table 2).

Table 2: Teeth sensitivity – tactile method.

Teeth Sensitivity – Air Blast Method

After using Dabur Red Paste, a 35.95% (1.56X) and 37.19% (1.59X) reduction in tooth sensitivity was observed at 1 minute and 30 minutes post-brushing on Day 1, respectively. Following 30 days of continuous use, a reduction of 57.85% (2.37X) was recorded at both time points. By Day 60, the reduction further reached 79.75% (79.75X) at 1 minute and 30 minutes post-brushing, with statistical significance observed across all time points (p-value < 0.001). These findings demonstrate that continuous use of Dabur Red Paste effectively reduces tooth sensitivity over time (Table 3).

Table 3: Teeth sensitivity – air blast method.

Teeth Sensitivity – Cold Water Method

After using the test product, a reduction in tooth sensitivity of 32.01% (1.47X) and 32.81% (1.49X) was observed at 1 minute and 30 minutes post-brushing on Day 1, compared to the baseline. Following 30 days of use, tooth sensitivity decreased by 59.53% (2.47X) at both time points. With continuous use for 60 days, a significant reduction of 84.19% (6.33X) in tooth sensitivity was observed at 1 minute and 30 minutes post-brushing. These findings indicate that the test product effective in reducing tooth sensitivity with consistent use over time (Table 4).

Table 4: Teeth sensitivity-cold water method.

Teeth Sensitivity: Acidic Solution Method

As compared to the baseline, 15.34% (1.17X) and 22.96% (1.19X) reduction observed post brushing at 1 min and 30 min of the brushing on Day 01. 41.23% (1.70X) reduction observed post 1 min and 30 mins of the brushing on Day 30. While continuous 60 days of the usage of the test product the reduction reached to 72.22% (3.60X) and 71.76% (3.54X) at 1 min and 30 mins f the brushing respectively. The results were found to be statistically significant across all the timepoint with p-value <0.001 (Table 5).

Table 5: Teeth sensitivity – acidic solution method.

Teeth Freshness – TANITA

On Day 60, before brushing, 4 subjects (13.79%) scored 0, indicating no odour, 16 subjects (55.17%) scored 1, indicating slight odour, 8 subjects (27.59%) scored 2, indicating moderate odour and 1 subject (3.45%) scored 3, indicating strong odour. On Day 61, before brushing, 7 subjects (24.14%) scored 0, indicating no odour, 15 subjects (51.72%) scored 1, indicating slight odour and 7 subjects (24.14%) scored 2, indicating moderate odour.

Organoleptic Assessment- Dentist Assessment

On Day 60, before brushing, 9 subjects (31.03%) scored 0, indicating no odour, 15 subjects (51.72%) scored 1, indicating barely noticeable odour, 2 subjects (6.9%) scored 2, indicating slight but clearly noticeable odour, 2 subjects (6.90%) scored 3, indicating moderate odour and 1 subject (3.45%) scored 4, indicating strong odour. On Day 61, before application of the test product, 9 subjects (31.03%) scored 0, indicating no odour, 15 subjects (51.72%) scored 1, indicating barely noticeable odour and 5 subjects (17.24%) scored 2, indicating slight but clearly noticeable odour.

Instant and 24 Hours Reduction in Plaque 

At baseline on Day 01, the mean was 2.93 ± 0.56 which shifted to 1.81 ± 0.40 after application of the test product at T1 min indicates that test product provides instant reduction in the plaque deposition. While on Day 60 before brushing the mean was reduced to 1.47 ± 0.38 and on Day 61 (before brushing), the mean was reduced to 1.34 ± 0.39 indicates that test product provides protection against the plaque up to 24 hours.

Instant and 24 Hours Reduction in Gingivitis

In the gingivitis assessment, mean was 2.29 ± 0.20 at baseline and post 1 min of the brushing indicates that there was no any instant change observed. At Day 60 and Day 61 (before brushing), again the mean was same, 1.09 ± 0.31 indicates that no change in the gingivitis post 24 hours of brushing.

Change in Teeth Sensitivity After 24 Hours (Table 6).

Tactile Method: On visit 03, Day 60, mean VAS Pain score was 3.90 which reduced to 3.21 at Day 61 (before brushing) indicates that test product reduced the test sensitivity upto 24 hours.

Air Blast Method: On visit 03, Day 60, mean VAS Pain score was 3.48 which reduced to 2.45 to Day 61 (before brushing) indicates that test product reduced the teeth sensitivity upto 24 hours.

Cold Water: On visit 03, Day 60, mean VAS Pain score was 3.03 which reduced to 1.79 at Day 61 (before brushing) indicates test product provides upto 24 hours reduction in tooth sensitivity.

Acidic Solution: On visit 03, Day 60, mean VAS Pain score was 3.38 which reduced to 2.55 at Day 61 (before brushing) indicates that test product provides upto 24 hours teeth sensitivity.

Table 6: Teeth sensitivity- 24-hour protection.

Change in Teeth Sensitivity Instantly (Table 7).

Tactile Method: At baseline before brushing on Day 01, the mean was 6.90 which was reduces to 5.79 post 1 min of the brushing on Day 01 indicates that test product provides the instant reduction in teeth sensitivity.

Air Blast Method: At baseline before brushing on Day 01, the mean was 8.34 which was reduces to 5.34 post 1 min of the brushing on day 01 indicates that test product provides the instant reduction in teeth sensitivity.

Cold Water: At baseline before brushing on Day 01, the mean was 7.83 which was reduces to 5.34 post 1 min of the brushing on day 01 indicates that test product provides the instant reduction in teeth sensitivity.

Acidic Solution: At baseline before brushing on Day 01, the mean was 7.07 which was reduces to 5.72 post 1 min of the brushing on day 01 indicates that test product provides the instant reduction in teeth sensitivity.

Table 7: Teeth sensitivity-instantly reduction.

Conclusion

The herbal oral care product demonstrated clinically validated efficacy in significantly reducing tooth sensitivity, plaque buildup, gingival inflammation and root caries, while delivering long-lasting freshness and enhanced gum strength. Over a 60-day period, participants experienced measurable improvements across all key oral health parameters, with zero reported adverse effects, confirming the product’s excellent safety profile. Powered by a synergistic blend of traditional herbal ingredients such as Maricha, Pippali, Shunthi and Pudina; the formulation offers a natural, effective and well-tolerated solution for comprehensive oral care. These findings provide robust scientific validation for the product’s positioning as a holistic, natural solution for effectively managing tooth hypersensitivity and enhancing overall oral health.

Conflict of Interest

The authors declare that they have no conflicts of interest with the contents of the article.

Funding

Study have been sponsored by Dabur India Ltd.

Authors’ Contributions

All authors have contributed equally to this work and have reviewed and approved the final manuscript for publication.

Reference

1. Charaka Samhita. Sutrasthana and Chikitsasthana chapters on oral health and Trikatu usage.
2. Bhavaprakash Nighantu. Descriptions of Maricha, Pippali, Shunthi and Lavanga.
3. Nadkarni KM. Indian materia medica. Mumbai. Popular Prakashan. 2000.
4. Kirtikar KR, Basu BD. Indian medicinal plants. Dehradun: International Book Distributors. 1999.
5. Warrier PK. Indian Medicinal Plants: A Compendium of 500 Species. Hyderabad: Orient Longman. 1996.
6. Marsh PD. Controlling the oral biofilm with antimicrobials. J Dent. 2010;38(Suppl 1):S11-5.
7. Braga MM, Oliveira LB, Bonini GA, Bönecker M, Mendes FM. Feasibility of the International Caries Detection and Assessment System (ICDAS-II) in epidemiological surveys and comparability with standard World Health Organization criteria. Caries Res. 2009;43(4):245-9.
8. Dababneh RH, Khouri AT, Addy M. Dentine hypersensitivity-an enigma? A review of terminology, mechanisms, aetiology and management. Br Dent J. 1999;187(11):606-11.
9. Liu Y, Wang L, Wang Y, Wang P. Organoid-based biosensors for taste discrimination. Biosens Bioelectron. 2021;192:113498.